Bewegungsapparat

Langerhans Cell Histiocytosis

  1. rare spectrum of disorders in children with histiocytic infiltration of various organ systems
  2. Letterer-Siwe disease: aggressive multiorgan system disease, high mortality
  3. Hand-Schüller-Christian: intermediate, chronic multiorgan system disease
  4. LCH of Bone: sole bone involvement
  5. bone lesions have variety of appearances, eg aggressive, permeative pattern
  6. Spine: vertebra plana
  7. Skull: beveld-edge sharply defined lesion, button sequestrum
  8. DDX: Ewing sarcoma, osteomyelitis
 
 

Diskussion